Tom Maniatis, PhD

Departments And Divisions

  • Department of Biochemistry and Molecular Biophysics
  • Isidore S. Edelman Professor of Biochemistry and Molecular Biophysics
  • Chair, Biochemistry & Molecular Biophysics
  • Director, Columbia University Precision Medicine Initiative
  • Executive Committee, Zukerman Mind Brain Behavior Institute
  • Member, Board of Directors, The New York Genome Center
Tom Maniatis, <span>PhD</span>

The primary focus of my lab during the past 10 years has been in two areas: 1. Disease mechanisms of ALS, which involves a combination of human genetic, stem cell and animal model approaches, and 2. The structure and function of the clustered protocadherin (Pcdh) genes.  We have used behavioral assays in both projects to characterize the phenotypic consequences of mutations in mouse models.  The ALS animal model work has involved the use of various neuromuscular behavioral studies of the SOD1 G93A mouse model, while the protocadherin project has involved studies of both motor function and affective behavior (depression and anxiety).  Manuscripts describing both studies are under review. The most recent ALS work is a study of the role of autophagy in ALS disease progression, and these studies involved various studies of motor function such as the rotarod test for motor coordination and muscle strength.  The protocadherin studies involve various assays for affective function (anxiety and depression), in Pcdha gene cluster deletion mice. We have shown that these mice display a cell-autonomous serotonergic wiring phenotype, and have characterized the behavioral consequences.  Recent human genetic studies from other laboratories have implicated the Pcdh gene cluster in autism and other neurological diseases.  We have generated a series of well-characterized deletion mutants in the Pcdh gene cluster, and are characterizing their behavioral phenotypes. Thus, the behavior core is central to our ongoing and future studies.

    Education & Training

  • BA, 1965 Biology, University of Colorado
  • MS, 1967 Chemistry, University of Colorado
  • PhD, 1971 Molecular Biology, Vanderbilt University

Lab Locations

  • Hammer Health Sciences Building

    701 West 168th Street
    Room 601
    New York, NY 10032
    Phone:
    (212) 305-3669
    Email:
    tm2472@cumc.columbia.edu

Research Interests

  • Regulation of RNA Transcription and Splicing
  • The Role of Neuroinflammation in ALS
  • Neurobiology of Disease
  • Synapses and Circuits
  • Stem Cell Biology
  • ALS Disease Mechanisms
  • Genetic Basis of Neurological Diseases

Lab Projects

  • ALS Disease Mechanisms
  • Development of Neural Circuits
  • Protocadherin gene expression and function

Lab Members

  • Daniele Canzio, PhD, Postdoctoral Fellow
  • Monica Carrasco, PhD, Associate Research Scientist
  • Weisheng Chen, PhD, Associate Research Scientist
  • Maxime Chevee, Tech B
  • Jackie de Vegvar, Tech B
  • aolo Guarnieri, MD, Associate Research Scientist
  • Elena Kandror, BA, Graduate Student
  • Tom Roberts, BS, Tech B
  • Noam Rudnick, BS, MD/PhD Student
  • Helaina Skop, BS, Graduate Student
  • Tenzin, Lab Member
  • Chan Aye Thu, PhD, Postdoctoral Fellow
  • Andrew Williams, PhD, Postdoctoral Fellow
  • Junqiang Ye, PhD, Research Associate
  • Jin Zhang, PhD, Postdoctoral Fellow
  • Amy Kirner, BS, Tech B
  • Jennifer Liao, BA, Tech B
  • Tom Maniatis, PhD, Chairman
  • George Mountoufaris, BSc, Graduate Student
  • Chiamake Nwakeze, BA, Tech B
  • Sean O'Keeffe, BSc, Computational Biologist
  • Hemali Phatnani, PhD, Associate Research Scientist
  • Gloria Recio, Technician Assistant

Collaborators

Richard Axel - Role of protocadherins in olfactory receptor neuron wiring

Tom Jessell - Astrocyte/motor neuron interactions in ALS

Charles Zuker - single cell analysis of taste receptors

Publications

Publications List