Departments And Divisions
- Department of Neurology
Division of Aging and Dementia
- Department of Psychiatry
Division of Cognitive Neuroscience
- Boris and Rose Katz Professor of Neurology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center and in Radiology)
- Director, Alzheimer's Disease Research Center
The hippocampal formation functions as a three-dimensional network. We have been developing MRI approaches that allow us to investigate the hippocampus as a circuit in humans and, most recently, in mice to understand how the hippocampus functions during normal associative memory, and how the hippocampus fails during aging and Alzheimer's disease.
We have focused on the longitudinal axis of the hippocampus in our studies of normal memory where we have human subjects process auditory and visual stimuli, in isolation or paired in time. Results from these studies suggest specific circuit mechanisms for how the hippocampus encodes and combines information during associative memory. We are currently extending this area of investigation into mice, which will allow us to uncover potential cellular and molecular mechanisms that underlie these circuit mechanisms. We have focused on the transverse axis of the hippocampal formation in our efforts to understand how the hippocampus fails in aging and Alzheimer's disease. Toward this goal, we have developed novel imaging approaches that measure hippocampal function with microscopic resolution.
These approaches allow us to assess the multiple hippocampal subregions that make up the transverse circuit—individually to pinpoint the site of dysfunction, and simultaneously to correct for circuit-wide effects. We have used this approach to generate patterns of hippocampal dysfunction in humans with Alzheimer's disease and normal aging, as well as in mouse models with Alzheimer's disease and normal aging. Taken together, the results suggest that MRI maps of hippocampal dysfunction can dissociate causes of memory decline. We are currently testing whether these MRI approaches can be used as a diagnostic tool for early Alzheimer's disease, and whether these MRI approaches can be exploited for drug development.
- Internal Medicine
Areas of Expertise
- Memory Impairment
- Columbia University College of Physicians and Surgeons
- Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
- Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
Education & Training
College of Physicians and Surgeons (P&S)630 West 168th Street
New York, NY 10032
- (212) 305-9194
- 630 West 168th Street
P&S Box 16
New York, NY 10032
- (212) 305-9194
Honors & Awards
- Irving Center Scholar Award
- AFAR Paul Beeson Physician Faculty Scholar in Aging Research Award: Functional analysis of the hippocampal formation in age-related memory decline
- NIH Mentored Patient-Oriented Research Career Development Award: Longitudinal Analysis of Age Related Memory Decline
- NIH Alzheimer's Disease Research Center Award (senior investigator): fMRI analysis of hippocampal regions in aging and Alzheimer's disease
- Brain Imaging
- Neurobiology of Disease
- Neurobiology of Learning and Memory
- Neural Degeneration and Repair
- Small, S.A. (2002). The longitudinal axis of the hippocampal formation: Its anatomy, circuitry and role in cognitive function. Rev. Neurosci., 13: 183-194
- Small, S.A., Tsai, W.Y., DeLaPaz, R., Mayeux, R., Stern, Y. (2002). Imaging hippocampal function across the human life span: Is memory decline normal or not? Ann. Neurol., 51: 290-295.
- Small, S.A., Nava, A.S., Tsai, W.Y., DeLaPaz, R., Mayeux, R., Stern, Y. (2001). Circuit mechanisms underlying memory encoding and retrieval in the long axis of the hippocampal formation. Nature Neuro., 442-449.
- Small, S.A., Wu, E.X., Bartsch, D., Perera, G.M., Lacefield, C.O., DeLaPaz, R., Mayeux, R., Stern, Y., and Kandel, E.R. (2000). Imaging physiologic dysfunction of individual hippocampal subregions in humans and genetically modified mice. Neuron, 28: 653-664.
- Small, S.A., Perera, G.M., DeLaPaz, R., Mayeux, R., and Stern, Y. (1999). Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer’s disease. Ann. Neurol., 45: 466-472.
For a complete list of publications, please visit PubMed.gov