Departments And Divisions
- Department of Psychology (Columbia University)
- Assistant Professor of Psychology (Columbia University)
Our research examines the neurobiology of affective development during childhood and adolescence. Affective development is incredibly protracted in the human, which provides us with an extended period of plasticity for learning from environmental cues. Our laboratory’s questions include a focus on the powerful influences of early social experiences. Using a combination of functional magnetic resonance imaging (fMRI), laboratory-based behavior, and physiological methods, our research spans a wide developmental age range from infancy to adulthood to I) characterize developmental trajectories of human affective neurobiology (e.g., amygdala, hippocampus, striatum, prefrontal cortex), II) understand how early social environments influence this neurobiology, and III) identify effects of early-life stress on the development of affective neurobiology. Our hypotheses about human development are influenced by both human and non-human animal literatures on affective development, and I have approached these aims by studying normative human development and development following exposure to early-life adversity.
Schermerhorn Hall1190 Amsterdam Ave
406 Mail Code: 5501
New York, NY 10027
- (212) 854-1925
- (212) 854-3609
- Developmental Affective Neuroscience
- Human Subcortical-Cortical Development
- Early-Life Stress
- Childhood and Adolescence
- Silvers, J.A., Lumian, D. Gabard-Durnam, L., Gee, D.G., Goff, B., Fareri, D., Caldera, C., Flannery, J., Telzer, E.H., Humphreys, K., & Tottenham, N. (in press) Previous institutionalization is followed by broader amygdala-hippocampal-PFC network connectivity during aversive learning in human development. Journal of Neuroscience.
- Green, S., Goff, B., Gee, D. G., Gabard-Durnam, L., Flannery, J., Telzer, E., Humphreys, K.L., Louie, J., & Tottenham, N. (in press). Amygdala discrimination predicts future anxiety in youth with early deprivation. Journal of Child Psychology and Psychiatry.
- Fareri, D. & Tottenham, N. (in press). Effects of early life stress on amygdala and striatal development. Developmental Cognitive Neuroscience.
- Gabard-Durnam, L., Gee, D.G, Goff, B., Flannery, J., Telzer, E; Humphreys, K., Lumian, D; Fareri, DS; Caldera, C; Tottenham, N. (in press). Stimulus-elicited connectivity influences resting-state connectivity years later in human development: a prospective study. *authors contributed equally. Journal of Neuroscience.
- Callaghan, B. & Tottenham, N. (in press). The Stress Acceleration Hypothesis: Effects of early-life adversity on emotion circuits and behavior. Current Opinion in Behavioral Sciences.
- Callaghan, B. & Tottenham, N. (in press). The Neuro-Environmental Loop of Plasticity: A cross-species analysis of parental effects on emotion circuitry development following typical and adverse caregiving. Neuropsychopharmacology Reviews.
- Fareri DS, Gabard-Durnam L, Goff B, Flannery J, Gee DG, Lumian DS, Caldera C, Tottenham N. (2015) Normative development of ventral striatal resting state connectivity in humans. Neuroimage. 118, 422-437.
- Gee, D.G., Gabard-Durnam, L., Telzer, E.H., Humphreys, K.L., Goff, B., Shapiro, M., Flannery, J., Lumian, D.S., Fareri, D.S., Caldera, C., & Tottenham, N. (2014). Maternal buffering of human amygdala–prefrontal circuitry during childhood. Psychological Science, 25(11), 2067-2078. PMC4377225
- Gabard-Durnam, L., Flannery, J., Goff, B., Gee, D.G., Humphreys, K.L., Telzer, E.H., Hare, T.A., & Tottenham, N. (2014).The development of human amygdala functional connectivity at rest from 4 to 23 Years: a cross-sectional study. Neuroimage, 95, 193-207. PMC4305511
- Tottenham, N. (2014). The Importance of Early Environments for Neuro-Affective Development. Current Topics in Behavioral Neurosciences, 16, 109-129. PMC4021037
- Gee, D.G., Gabard-Durnam, L., Flannery, J., Goff, B., Humphreys, K.L., Telzer, E.H., Hare, T.A., Bookheimer, S.Y., Tottenham, N. (2013). Early Developmental Emergence of Human Amygdala-PFC Connectivity after Maternal Deprivation. Proceedings of the National Academy of Sciences, 110(39):15638-15643. PMC3785723
- Olsavsky, A., Telzer, E.H., Shapiro, M., Humphreys, K.L., Flannery, J., Goff, B., & Tottenham, N. (2013). PMC3818506
- Telzer, E.H., Flannery, J., Shapiro, M., Humphreys, K., Goff, B., Gabard-Durnam, L., Gee, D.G., & Tottenham, N. (2013). Early experience shapes amygdala sensitivity to race: An international adoption design. Journal of Neuroscience, 33(33) 13484-8. PMC3742934
- Gee, D.G., Humphreys, K.L., Flannery, J., Goff, B., Telzer, E.H., Shapiro, M., Hare, T.A., Bookheimer, S.Y., Tottenham, N. (2013).A Developmental Shift from Positive to Negative Connectivity in Human Amygdala-Prefrontal Circuitry. Journal of Neuroscience, 33(10)4584-4593. PMC3670947
- Goff, B. Gee, D.G., Telzer, E.H., Humphreys, K.L., Gabard-Durnam, L., Flannery, J., Tottenham, N. (2013). Reduced nucleus accumbens reactivity and adolescent depression following early-life stress. Neuroscience, 249, 129-138. PMC3646076
- Telzer, E.H., Humphreys, K., Shapiro, M., & Tottenham, N. (2013). Amygdala sensitivity to race is not present in childhood but emerges over adolescence. Journal of Cognitive Neuroscience, 25(2), 234-244. PMC3628780
- Tottenham, N., Hare, T.A., Millner, A., Gilhooly, T.,Zevin, J.D. & Casey, BJ (2011). Elevated Amygdala Response to Faces Following Early Deprivation. Developmental Science, 13(1), 46-61. PMC3050520
- Tottenham, N., Hare, T., Quinn, B., McCarry, T., Nurse, M.,Gilhooly, T., Millner, A., Galvan, A., Davidson, M., Eigsti, I.M., Thomas, K.M., Freed, P., Booma, E.S., Gunnar, M., Altemus, M., & Aronson, J., Casey, B.J. (2010) Prolonged institutional rearing is associated with atypically larger amygdala volume and difficulties in emotion regulation. Developmental Science, 13 (1), 46-61. PMC2817950