Departments And Divisions
- Department of Neuroscience
- Department of Neurology
Division of Critical Care and Hospitalist Neurology
- Department of Psychiatry
Division of Neurobiology and Behavior
- David Mahoney Professor of Brain and Behavior (in Neuroscience and Neurology [in Psychiatry and Ophthalmology])
- Director, Mahoney Center
We study the psychophysics and physiology of cognitive processes in the monkey, using single unit recording, iontophoresis, and careful behavioral measurements. The thrust of the lab has been understanding the physiology of visual attention - how the brain selects important objects in the visual field for further processing - and the generation of spatially accurate behavior despite a constantly moving eye. Current projects include studying the role of somatosensory cortex in the eye-position modulation of visual responses in parietal cortex; studying a newly discovered untuned cholinergic modulatory signal in the monkey parietal cortex that predicts how well the monkey will perform on the current trial of a difficult task, correlates inversely with the monkey's recent history of success or failure, and correlates positively with the neuron's response to a visual transient; studying the involuntarily establish of spatial memory memory in the lateral intraparietal area and the parahippocampal gyrus, studying the fine structure of perisaccadic remapping of visual receptive fields, and studying the role of the cerebellum in visualmotor associations. Recent discoveries in the laboratory include the demonstration of a predictive relationship of parietal activity to both saccadic reaction time and visual attention; the demonstration that the lateral parietal area acts as a linear summing junction for at least three independent signals: a saccadic signal, and undifferentiated visual signal, and a cognitive signal, and the proprioceptive representation of eye position in monkey area 3a of primary somatosensory cortex, and the time course of eye-position modulation of visual responses in the parietal cortex..
Areas of Expertise
- Critical Care
- Research Studies
- Harvard Medical School
- Residency: Harvard Longwood Psychiatry
Education & Training
Herbert Pardes Building of the New York State Psychiatric Institute1051 Riverside Drive
New York, NY 10032
- (212) 543-6931
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Kolb Research Annex40 Haven Avenue
Unit 87, 5th floor, Room 561
New York, NY 10032
- (646) 774-7389
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1975-1978 Research Neurologist and Chief, Section on Experimental Neurology, Armed Forces Radiobiology Research Institute, Bethesda, Maryland
1978-1981 Research Medical Officer, Laboratory of Sensorimotor Research, NEI, NIH.
1981-1992 Chief, Section on Neuroophthalmological Mechanisms, Laboratory of Sensorimotor Research.
1992-1997 Senior Medical Research Officer, Laboratory of Sensorimotor Research.
1997- 2001 Chief, Section of Neuroophthalmological Mechanisms; Deputy Scientific Director for Bldg. 49, NEI.
1977- 2001 Assistant Professor of Neurology through Professor of Neurology at the NIH, Georgetown University School of Medicine. Attending Neurologist, Georgetown University Hospital
2001-present David Mahoney Professor of Brain and Behavior, in the Departments of Neuroscience, Neurology, Psychiatry, and Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY. Attending Neurologist, New York-Presbyterian Hospital; Director, Division of Neurobiology and Behavior, New York State Psychiatric Institute.
Graduate Seminar in Systems Neuroscience
Lectures in the Basic and Clinical Neuroscience Course
Section teaching in Clinical Correlates of Basic Neuroscience
Resident and student teaching on the CUMC neurology hospitalist service
Member, The Kavli Institute for Brain Science
Past president, Society for Neuroscience, currently Chair of the Committee on Animal Research, SfN
Member, FENS Committee on ANimal Research
Member National Academy of Sciences
Fellow American Association for the Advancement of Science, American Academy of Arts and Sciences.
Member American Neurological Association, American Academy of Neurology
Honors & Awards
Honors: Member, Phi Beta Kappa (1963), Alpha Omega Alpha (1968)
1972 S. Weir Mitchell Award, American Academy of Neurology
1982 Elected to the American Neurological Association
1997 Elected an Associate of the Neuroscience Research Program of the Neuroscience Institute.
1999 Wundt Lecturer, Max Planck Institute for Cognitive Neuroscience, Leipzig
1999 Graduation Visiting Professor of Neurology, Longwood Program, Harvard Medical School.
1999 Grass Traveling Lecturer, Queens University, Kingston, Ontario
2000 Sprague Lecturer, Mahoney Neuroscience Institute, University of Pennsylvania
2001 Special Lecturer, Society for Neuroscience Annual Meeting.
2002 Heller Lecturer in Computational Neuroscience, Hebrew University, Jerusalem, Israel.
2004 Mary G. Notter Lecturer in Neurobiology, University of Rochester
2006 Bodian Lecturer, Johns Hopkins University
2006 Elected a Fellow of the American Academy of Arts and Sciences
2006 Louis P. Rowland Teaching Award, Columbia University Department of Neurology
2007 Eli Lilly Lecturer, University of Montreal
2008 Elected a Fellow of the American Association for the Advancement of Science
2009 Elected a member of the Dana Alliance
2009 Inaugural Colloquium Lecture, Institute of Neuroscience, Universite Catholique de Louvain la Neuve.
2010 Keynote Speaker, European Primate Neurobiology Meeting, Tuebingen, Gemany
2010 David Robinson Lecturer, Department of Biomedical Engineering, Johns Hopkins
2010 Swammerdam Lecture, Netherlands Neuroscience Institute.
2011 Plenary Lecturer, International Conference on Cognitive and Neural Systems, Boston University
2011 Elected to the National Academy of Sciences
2011 Patricia Goldman-Rakic Award for Cognitive Neuroscience, Brain and Behavior Research Foundation.
- Neurobiology of Learning and Memory
- Cognitive/Systems Neuroscience
- Sensory Physiology
- Synapses and Circuits
- Mulugeta Semework, Postdoctoral Fellow
- Linus Sun, Instructor in Neurology (in Ophthalmology)
- Xiaolan Wang, Senior Research Associate
- Anna Ipata, Senior Research Associate
1. Duhamel, J.-R., Colby, C.L., and Goldberg, M.E. The updating of the representation of visual space in parietal cortex by intended eye movements. Science, 255: 90-92, 1992.
2. Gottlieb, J., Kusunoki, M., and Goldberg, M.E. The representation of visual salience in monkey parietal cortex Nature 391: 481-484, 1998.
3. Hasegawa, R.P., Blitz, A.M., Geller, N. and Goldberg, M.E. Neurons in monkey prefrontal cortex that track past or predict future performance. Science 290:1786-9, 2000.
4. Bisley, JW and Goldberg, M.E. Neuronal Activity in LIP and Spatial Attention. Science, 299:81-86, 2003.
5. Ipata AE, Gee AL, Goldberg, ME and Bisley, JW. Activity in the lateral intraparietal area predicts the goal and latency of saccades in a free viewing visual search task. J. Neurosci. 26: 3656-61, 2006.
6. Ipata AE, Gee AL, Bisley, JW and Goldberg, ME. Responses in the lateral intraparietal area to a popout stimulus are reduced if it is overtly ignored. Nat. Neurosci. 9:171-6, 2007.
7. Wang, X, Zhang,M, Cohen, IS, and Goldberg,ME. The proprioceptive representation of eye position in monkey primary somatosensory cortex, Nat. Neuroscience, 10:, 640-646, 2007.
8. Ganguli S, Bisley JW, Roitman j, Shalden M, Goldberg ME, Miller K . . One dimensional dynamics of attention and decision making in LIP. Neuron, 58:15-25, 2008.
9. Gee, A. L., A. E. Ipata, et al. "Neural enhancement and pre-emptive perception: the genesis of attention and the attentional maintenance of the cortical salience map." Perception 37(3): 389-400, 2008.
10. Ipata, A. E., A. L. Gee, et al. "Neurons in the lateral intraparietal area create a priority map by the combination of disparate signals." Exp Brain Res. 171: 37-45, 2009.
11. Bisley JW, Goldberg ME. Attention, intention, and priority in the parietal lobe. Ann. Rev. Neurosci 33:1-21, 2010.
12. Falkner AE, Krishna BS, Goldberg ME. Surround suppression sharpens the priority map in LIP. J. Neurosci, 38:12787-97, 2010.
13. Gee AL, Ipata AE, Goldberg ME. Activity in V4 reflects the direction, but not the latency, of saccades during visual search. J Neurophysiol. 104: 2187-2193, 2010.
14. Xu Y, Wang X, Peck C, Goldberg, ME. The time course of the tonic oculomotor proprioceptive signal in area 3a of somatosensory cortex. J. Neurophysiology, 106:71-7, 2011.
15. Ipata, A., A. Gee, et al. "Feature attention evokes task-specific pattern selectivity in V4 neurons." Proceedings of the National Academy of Sciences of the United States of America 109(42): 16778-16785. PMID: 23043119, 2012.
16. Xu, B., C. Karachi, et al. "The postsaccadic unreliability of gain fields renders it unlikely that the motor system can use them to calculate target position in space." Neuron 76(6): 1201-1209. PMID- 23259954, 2012.
17. Falkner AL, Krisha BS, & Goldberg ME. Spatial Representation and Cognitive Modulation of Response Variability in the Lateral Intraparietal Area Priority Map. J Neurosci. 2013 Oct 9;33(41):16117-30, 2013.
18. Steenrod S, Phillips MH, & Goldberg ME. The lateral intraparietal area (LIP) codes the location of saccade targets and not the dimension of the saccades that will be made to acquire them. J Neurophysiol 109(10):2596-2605, 2013.
19. Zhang, M., X. Wang and M. E. Goldberg. "A spatially nonselective baseline signal in parietal cortex reflects the probability of a monkey's success on the current trial." Proc Natl Acad Sci USA 111(24): 8967-8972, 2014.
20. Krishna BS, Ipata AE, Bisley JW, Gottlieb J, Goldberg ME. Extrafoveal preview benefit during free-viewing visual search in the monkey. J Vis. 8:14(1). pii: 6. doi:10.1167/14.1.6, 2014.