Maura Boldrini, MD, PhD

Departments And Divisions

  • Department of Psychiatry
    Division of Molecular Imaging and Neuropathology
  • Research Scientist in the Department of Psychiatry and Postdoctoral Residency Fellow in the Department of Psychiatry
Maura Boldrini, <span>MD, PhD</span>

In my laboratory, current research focuses on studying adult neurogenesis and angiogenesis in the human brain. Adult neurogenesis is a mechanism of structural plasticity occurring in mammals including humans, which is necessary for learning and coping, shows adaptation to environment conditions and a significant response to medications. My research focuses on studying stem cells and their progeny in the human adult brain in the context of psychiatric, neurodevelopmental and neurodegenerative disorders. I am quantifying stem cells, cells at different stages of maturation on the neuronal and glial lineage and angiogenesis in the human autopsy brain. I am assessing the impact of psychiatric disorders, age, stress and psychopharmacologic treatment on hippocampal neuroplasticity. I am studying trophic factors expression in correlation with levels of angiogenesis and neurogenesis in the human hippocampus.

I am currently involved as Principal Investigator or Co-Investigator in research projects studying:

1. The relationship between trophic factors expression in the hippocampal dentate gyrus (DG) and its correlation with the amount of neurogenesis and angiogenesis in the human brain.

2. Human adult neurogenesis in normal subjects and individuals with mood disorders and the effects of antidepressant treatment on human adult neurogenesis.

3. Molecules controlling cell proliferation, maturation and survival in depressed suicide compared with non-suicide depressed individuals and controls without psychiatric diagnosis.

4. Angiogenesis and cell proliferation in the postmortem temporal cortex of autism donors and matched normal developing individuals.

5. Neurobiological and Developmental Antecedents to Suicidal Behavior, assessing how reported childhood adversity can affect hippocampal neuroplasticity later in life.

6. Correlates of depression or schizophrenia versus suicide, quantifying tryptophan hydroxylase protein in the serotonergic neurons of the brainstem.

I am interested in studying mechanisms involved in cell maturation and survival and how they are affected in mood disorders and with antidepressant treatment, and assessing the role of apoptosis in the cellular balance of the hippocampus in depression. I am investigating the relationship between the serotonergic system and neurogenesis, assessing the levels of expression of serotonin receptors and degree of neurogenesis in the human hippocampus. I am also investigating the effect of other medications, a reported history of childhood adversity and age on adult human neurogenesis, angiogenesis and trophic factors.

Lab Locations

  • NYSPI-Kolb Research Building

    622 West 168th Street
    New York, NY 10032

Contact Info

Past Positions

• Academic Appointments

08/2014-Curr.  Columbia University, Department of Psychiatry  New York, NY
  Research Scientist

08/2014-Curr.  Columbia University, Department of Psychiatry  New York, NY
  Postdoctoral Residency Fellow

12/2008-Curr.  New York State Psychiatric Institute, Molecular Imaging & Neuropathology Division           New York, NY
  Research Scientist V

07/2013- 08/2014 Columbia University, Department of Psychiatry  New York, NY
  Associate Professor of Neurobiology (in Psychiatry)

12/2008-06/2013 Columbia University, Department of Psychiatry  New York, NY
  Assistant Professor of Clinical Neurobiology (in Psychiatry)

04/2005-10/2012 Univ. of Florence, Dept. of Neurological & Psychiatric Science
Tenured Researcher  Florence, Italy

07/2004-06/2006 Columbia University, Department of Psychiatry New York, NY
Adjunct Associate Research Scientist

10/2001-04/2005  Univ. of Florence, Dept. of Neurological & Psychiatric Sc.  Florence, Italy
Research Scientist 

07/1998-06/2000  New York State Psychiatric Institute, Department of Neuroscience Assistant Research Scientist New York, NY

• Hospital Appointments

10/2004-04/2005  Borgo San Lorenzo Hospital, Dept. of Mental Health Florence, Italy
Staff Psychiatrist, Inpatient and Outpatient Clinic

04/2003-10/2004 Pistoia Hospital, Department of Mental Health Pistoia, Italy
Staff Psychiatrist, Inpatient and Outpatient Clinic

Presentations

1993

  1. Salvadori C, Boldrini M, Di Stefano M. Spatial compatibility in visuomotor go-no-go RT task. Riunione Congiunta Society Italiana Di Biologia Sperimentale LXII Assemblea Generale, Society Italiana di Fisiologia XlV Congresso Nazionale, Society Italiana di Nutrizione Umana XXVI Riunione Generale. Pavia, Italy, September 8-10, 1993.

1995

  1. Toni C, Perugi G, Frare F, Boldrini M, Pedri S, Medda PP, Cassano GB. Neuropsychological test battery in patients with Panic Disorder/Agoraphobia. 8th Sardinian Conference of Neuroscience "Anxiety And Depression: Neurobiology, Pharmacology And Clinic". Villasimius, Italy, May 24-28, 1995.
  2. Perugi G, Benedetti A, Simonetti B, Boldrini M, Placidi G, Quilici C, Simoncini M, Sartini S, Toni C. Hypochondrias in Panic Disorder. X National Congress of The Italian Society Of Neuropsychopharmachology. Venice, Italy, September 27-29, 1995.

1996

  1. Toni C, Frare F, Mastrocinque C, Boldrini M, Simimoncini M, Mastalli L, Ramacciotti S, Nassini S, Lenzi M, Socci C, Simonini AE, Gemignani A, Pfanner C, Presta S, Perugi G. Comorbidity in patients with anxiety disorders. 1st National Congress of the Italian Society of Psychopathology (SOPSI) Turin, Italy, February 22-24, 1996.
  2. Placidi GP, Boldrini M, Caponi L, Bombardieri S. Non-organ specific autoantibodies in patients with psychiatric disorders. Primo Convegno Nazionale "Verso Una Biochimica Del Cervello -Prospettive In Psichiatria per la Ricerca e la Clinica" Pisa, Italy, May 24, 1996.
  3. Boldrini M, Placidi GP, Mosca M, Caponi L, Bombardieri S: Psychiatric disorders and immunological parameters in patients with Systemic Lupus Erythematosus. Third Congress Of The European Society For Clinical Neuropharmacology, Rome, Italy, October 28-30, 1996, J Neural Transm 103: I-Lix.

1997

  1. Placidi GP, Boldrini M, Ruffolo G, Marazziti D. Prevalence of psychiatric disorders in patients with diabetes mellitus. 2nd National Congress of the Italian Society of Psychopathology (SOPSI), Pisa, Italy, February 1997.
  2. Toni C, Cappa S, Boldrini M, Frare F, Pedri S, Medda P, Perugi G. Selective neuropsychological dysfunction in patients with panic disorder-agoraphobia. Biological Psychiatry 1997; 42:1s-297s

1998

  1. Placidi GP, Boldrini M, Lazzeri A, Palmieri G, Mengali F, Marazziti D, Placidi GF: Blood Levels of Thyroid Hormones in Patients with Psychiatric Disorders: 485 Subjects. 3rd National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 25- March 1, 1998
  2. Boldrini M, Placidi GP, Marazziti D: Application of Chaos Theories to Psychiatry 3rd National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 25- March 1, 1998
  3. Boldrini M, Placidi GP, Marazziti D, Cappa SF, Pfanner C, Placidi GF, Cassano GB: Indagine neuropsicologica in un campione di pazienti affetti da disturbo ossessivo compulsivo. GIDOC 1998, S. Vincent, Italy.
  4. Placidi GPA, Boldrini M, Caponi L, Marazziti D, Dell’Osso L, Cassano GB. Non organ-specific autoantibodies in patients with psychiatric disorders. 11th European Congress of Neuropsychopharmacology (ECNP), Paris, France, November 4, 1998.

1999

  1. Boldrini M, Underwood MD, Hsiung S, Kassir SA, Tamir H, Brennan KC, Dye CD, Mann JJ, Arango V. Fewer Serotonin Transporter mRNA Expressing Neurons in the Dorsal Raphe Nucleus of Suicide Victims. 29th Annual Meeting of the Society For Neuroscience October 23-28, 1999 Miami Beach, Florida.
  2. Boldrini M, Underwood MD, Kassir SA, Hsiung SC, Tamir H, Mann JJ, Arango V. Altered Serotonin Transporter Gene Expression In DRN Neurons of Suicide Victims. ACNP 1999 Annual Meeting. Acapulco 11-16 December 1999.
  3. Underwood MD, Arkhipov VV, Boldrini M, Kassir SA, Tamir H, Mann JJ, Arango V. Functional Anatomy Of The Serotonergic Supraependymal Plexus In Human Brain. 38th Annual Meeting of the American College of Neuropsychopharmacology (ACNP) 1999 Annual Meeting. Acapulco 11-16 December 1999.

2001

  1. Agostino D, Placidi GPA, Scarpato MA, Boldrini M, Del Rosso A, Pignone A, Bertinotti L, Di Primio C, Matucci Cerinic M. Quality of Life in SSc Patients: Relationships with Illness Clinical and Biologic Measures. 6th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, 21-25 February 2001.
  2. Boldrini M, Underwood MD, Kassir SA, Tamir H, Hsiung SC, Mann JJ, Arango V. Alteration of Serotonin Transporter Gene Expression in Serotonergic Neurons of Dorsal Raphe Nucleus in Suicide. 6th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, 21-25 February 2001.
  3. Boldrini M. Postmortem Study of Serotonergic System in Suicide. 6th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, 21-25 February 2001.
  4. Boldrini M, Placidi GP, Keilp J, Ellis SP, Placidi GF. Specificity of the Cognitive Deficit Observed in Obsessive-Compulsive Disorder. 6th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, 21-25 February 2001.
  5. Arango V, Underwood MD, Boldrini M, Mann JJ. Morphometric and Molecular Alterations in the Brainstem of Suicide Victims. 7th World Congress of Biological Psychiatry (WCBP), Berlin, 1-6 July, 2001.
  6. Arango V, Underwood MD, Boldrini M, Mann JJ. Serotonin Transporter Changes in the Brain of Suicide Victims. Collegium Internationale Neuropsychoparmacologicum (CINP), Budapest, Hungary, 20-23 September, 2001.
  7. Matucci-Cerinic M, Del Rosso A, Boldrini M, Placidi GP, D’Agostino D, Scarpato A, Pignone A, Placidi GF. SF36 as a potential tool for the evaluation of the quality of life in systemic sclerosis (SSC). 20th Congress Of The International League Of Association For Rheumatology, (ILAR), Edmonton, Alberta, Canada, August 26-30, 2001.
  8. Boldrini M, Underwood MD, Kassir SA, Mann JJ, Arango V. Increased tryptophan hydroxylase concentration in the brainstem raphe nucleus of depressed suicide victims compared to controls. 40th Annual Meeting of the American College of Neuropsychopharmacology (ACNP), December 9-13, 2001 Waikoloa, Hawaii.

2002

  1. Boldrini M, Underwood MD, Kassir SA, Bakalian MJ, Placidi GF, Sorbi S, Mann JJ, Arango V. Increased tryptophan hydroxylase in the brainstem raphe nucleus in depressed suicide victims. 7th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 17 –23, 2002.
  2. Boldrini M, Del Pace L, Martini A, Placidi GP, Biagi M, Nieri M, Gervasi G, Placidi GF, Cappa SF: Insight and Treatment Response in Obsessive-Compulsive Disorder: Relationship with Cognitive Function. 7th National Congress of the Italian Society of Psychopathology (SOPSI), February 17–23, 2002.
  3. Boldrini M, Nieri M, Placidi GP, Calvieri M, Ricca V, Del Pace L, Martini A, Biagi M, Gervasi R, Placidi GF, Cappa SF: Cognitive Function in Patients with Eating Disorders. 7th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 17-23, 2002.
  4. Boldrini M, Biagi M, Placidi GP, Del Pace L, Martini A, Nieri M, Simeone M, Simoni GL, Gervasi R, Placidi GF, Cappa SF. Cognitive Patterns Associated to Major Depression and Suicidal Behavior. 7th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 17 –23, 2002.
  5. Gervasi R, Murciano L, Bonanno C, Signori S, Biagi M, Restuccia G, Arena A, Placidi GP, Nieri M, Simeone M, Boldrini M, Placidi GF. Validation of a Self-Administered Affective Temperament Scale (TEMPS-S). 7th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 17 –23, 2002.
  6. Gervasi R, Murciano L, Bonanno C, Signori S, Placidi GP, Restuccia G, Simoni GL, Boldrini M, Placidi GF. Affective Temperament Concordance in Homozygous and Dizygous Twins. 7th National Congress of the Italian Society of Psychopathology (SOPSI), February 17 –23, 2002.
  7. Placidi GP, Murciano L, Arena A, Simeone M, Signori S, Biagi M, Boldrini M, Restuccia G, Placidi GF. Blood Cholesterol Levels In Suicide Attempters. 7th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 17 –23, 2002.

2003

  1. Placidi GP, Boldrini M, Turchi F, Martini A, Simoni G, Martini F, Simeone M, Arena A, Del Pace L, Murciano L, Placidi GF. Correlation Between Past Maniac Episode And Suicidal Behavior In Subjects With Mood Disorders. 8th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 25 –March 23, 2003.
  2. Boldrini M, Martini A, Placidi GP, Giromella A, Underwood MD, Kassir SA, Placidi GF, Mann JJ, Arango V. Gender Differences In Brainstem Serotonergic System Function. 8th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 25 - March 23, 2003.
  3. Boldrini M, Pampaloni I, Placidi GP, Martini A, Underwood MD, Kassir SA, Placidi GF, Mann JJ, Arango V. Analysis Of Rostral To Caudal Distribution Of Brainstem 5HT1a Receptors In Suicides And Controls. 8th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 25 - March 23, 2003.
  4. Boldrini M, Cavalieri E, Placidi GP, Simeone M, Nieri M, Biagi M, Placidi GF. Cognitive Function In Depressed Subjects With And Without Suicidal Behavior. 8th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 25 –March 23, 2003.
  5. Alari F, Murciano L, Marinoni M, Boldrini M, Giardinelli L. Cerebral Blood Flow Variations In Bipolar Disorder. 8th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, February 25 –March 23, 2003.
  6. Castagna M, Boldrini M, Nardi I, Giromella A, Becherini F.Immunoautoradiographic Characterization Of Serotonin Transporter In Human Pineal Gland, 19th ECNP, Ljubljana, Slovenia, 2003.
  7. Boldrini M, Castagna M, Nardi I, Giromella A, Martini A, Pampaloni I, Becherini F, Arango V. Serotonin Transporter Binding Density Changes Seasonally In The Human Pineal Gland. 42nd Annual Meeting of the American College of Neuropsychopharmacology (ACNP), 7-11 December 2003, San Juan, Puerto Rico.
  8. Becherini F, Giromella A, Boldrini M, Nardi I, Castagna M. Detection Of Serotonin Transporter In Human Pineal Gland. The Italian Society of Anatomical Pathology and Diagnostic Cytopathology (SIAPeC), Genoa, Italy 2003.

2004

  1. Boldrini M, Giromella A, Martini A, Rossi M, Pampaloni I, Arango V, Mann JJ, Placidi GF. Alterations Of Serotonergic System In Suicide. 9th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, 24-28 February 2004.
  2. Boldrini M, Martini A, Giromella A, Pampaloni I, Rossi M, Arango V, Placidi GF. Serotonin Transporter Protein Amount In The Raphe Of Subjects With Bipolar Disorder, Depression, Schizophrenia And Controls (15 Each) With And Without Suicide. 9th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, 24-28. February 2004.
  3. Boldrini M, Castagna M, Nardi I, Giromella A, Martini A, Pampaloni I, Becherini F, Placidi GF. Seasonal Changes Of Serotonin Transporter Binding In Human Epiphysis. 9th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, 24-28 February 2004.
  4. Boldrini M, Underwood MD, Martini A, Kassir SA, Mann JJ, Arango V. Distribution of Serotonin-1A Autoreceptors in the Dorsal Raphe Nucleus of Depressed Suicide Victims. 43rd Annual Meeting of the American College of Neuropsychopharmacology (ACNP), 7-11 December 2004, San Juan, Puerto Rico.

2005

  1. Boldrini M, Giromella A, Martini A, Rossi M, Becherini F, Castagna M, Sorbi S, Placidi GF. Serotonin transporter density in cortical areas of subjects with Alzheimer Disease and controls. 10th National Congress of the Italian Society of Psychopathology (SOPSI), Rome, Italy, 22-26 February 2005.
  2. Boldrini M, Underwood MD, Martini A, Rossi M, Pampaloni I, Placidi GF, Mann JJ, Arango V. Effect of Psychiatric Diagnosis and Suicide on Serotonin Transporter Protein in The Dorsal and Median Raphe Nuclei. SOBP 60th Annual Scientific Convention and Meeting May 19-21st, 2005 Atlanta, Georgia.
  3. Underwood MD, Bach-Mizrahi H, Boldrini M, Mann JJ, Arango V. Forebrain-Brainstem Serotonin Disconnect in Suicide. 13th World Congress of Psychiatry, 10-15th September 2005, Cairo, Egypt.

2006

  1. Boldrini M, Bovani R, Martini A, Cavalieri E, Rossi M, Placidi GF, Mann JJ. A predictive model of suicidal behavior in depressed subjects: cognitive and psychopathologic factors. SOPSI, February 21-25, 2006 Rome, Italy
  2. Boldrini M, Martini A, Bovani R, Giromella A, Rossi M, Arango V, Underwood MD, Placidi GF, Mann JJ. Analysis of subnuclear serotonin transporter density in dorsal raphe nucleus of subjects with schizophrenia, bipolar disorder, depression and controls. SOPSI, February 21-25, 2006 Rome, Italy
  3. Boldrini M, Underwood MD, Romoli AM, Giromella A, Martini A, Innocenti A, Bovani R, Mann JJ, Arango V. Lower Serotonin Transporter Protein in Selected Subnuclei of DRN in Schizophrenia compared with Major Depression, Bipolar Disorder and Controls. First International Congress on Hot Issues in psychiatry. March 23-25, 2006 Pisa, Italy
  4. Boldrini M, Underwood MD, Romoli AM, Innocenti A, Bovani R, Martini A, Mann JJ, Arango V. Less Serotonin Transporter Protein in Specific Dorsal Raphe Subnuclei in Schizophrenia. SOBP 60th Annual Scientific Convention and Meeting, May 18-20 2006,Toronto
  5. Boldrini M, Underwood MD, Martini A, Romoli AM, Rossi M, Mann JJ, Arango V. Brainstem raphe nucleus changes in suicide victims. 11th European Symposium on Suicide and Suicidal Behaviour, September 9-12 2006, Portoroz, Slovenia
  6. Boldrini M, Underwood MD, Romoli AM, Mann JJ, Arango V. Serotonin Transporter Immunoreactivity in DRN Subnuclei in Schizophrenia, Major Depression, Bipolar Disorder and Controls. 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP), 3-7 December 2006, San Juan, Puerto Rico

2007

  1. Arango V, Boldrini M, Bach-Mizrachi H, Mann JJ, Underwood MD. Serotonergic Risk Factors for Suicide. SOBP 62nd Annual Meeting, May 17-19, 2007 San Diego, CA
  2. Boldrini M, Underwood MD, Reisoli E, Lau J, Nardi I, Pasqualetti M, Mann JJ, Arango V. Serotonin transporter (SERT) mRNA expression in the brainstem in schizophrenia, major depression and bipolar disorder. Society for Neuroscience 2007. Nov 3-7, 2007 San Diego, CA
  3. Boldrini M, Bach-Mizrachi H, Kassir SA, Huang YY, Bakalian MJ, Underwood MD, Goldman D, Mann JJ, Arango V. Gene variations of serotonin transporter promoter (5HTTLPR) affect protein and mRNA expression in the human raphe nuclei. 46th ACNP Annual Meeting. Dec 9-13 2007 Boca Raton, FL

2008

  1. Boldrini M, Underwood MD, Lau J, Mann JJ, Arango V. Antidepressants increase progenitors cells in the human dentate gyrus. SOBP 63rd Annual Meeting, May 1-3, 2008, Washington, DC
  2. Boldrini M, Underwood MD, Hen R, Lau J, Palavicino-Maggio C, Bakalian MJ, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. "Antidepressant treatment increases neural progenitor cells in the dentate gyrus of the hippocampus of patients with Major Depressive Disorder". Society for Neuroscience. Nov 15-19, 2008, Washington, DC
  3. Boldrini M, Lau J, Underwood MD, Bakalian MJ, Rosoklija GB, Dwork AJ, Hen R, Mann JJ, Arango V. Effects of antidepressants and age on neural progenitors in adult human dentate gyrus. 47th ACNP Annual Meeting. Dec 6-11 2008 Scottsdale, AZ

2009

  1. Boldrini M, Underwood MD, Hsiung SC, Kassir SA, Escobar T, Bakalian MJ, Mann JJ, Arango V. Neuronal Tryptophan Hydroxylase is Lower in Suicide and Higher in Major Depression. SOBP 64th Annual Meeting, May 14-16, 2009, Vancouver, Canada
  2. Boldrini M, Burke KM, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. Antidepressants increase nestin-immunoreactive blood vessels in the human dentate gyrus. Society for Neuroscience 2008. Oct 17-21, 2009, Chicago, IL
  3. Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. Tricyclics and SSRIs increase neural progenitor cells in the human dentate gyrus of subjects with major depressive disorder. 48th ACNP Annual Meeting. Dec 6-10 2009 Hollywood, FL

2010

  1. Boldrini M. Antidepressants increase neural progenitor cells and capillaries in the human dentate gyrus. SOBP 65th Annual Meeting, May 20-22, 2010, New Orleans, Louisiana, USA
  2. Boldrini M. Neurogenesis, angiogenesis and synaptogenesis regulation by antidepressants. SOBP 65th Annual Meeting, May 20-22, 2010, New Orleans, Louisiana, USA
  3. Boldrini M, Burke KM, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. Lithium increases neural progenitor cells and vascularization in the dentate gyrus of subjects with bipolar disorder. Society for Neuroscience. November 13-17 San Diego, CA
  4. Boldrini M. The effect of antidepressant on cell replication in the human brain. XVII Meeting Italian Society of Neuropsychopharmacology (SINPF). Cagliari, September 22-25, 2010
  5. Boldrini M. Angiogenesis and neurogenesis potentiation by antidepressants in the human CNS. XVII Meeting Italian Society of Neuropsychopharmacology (SINPF). Cagliari, September 22-25, 2010
  6. Boldrini M. Antidepressants stimulate the proliferation of neural progenitor cells and capillaries in the human dentate gyrus. VI Symposium of the Italian Society of Pharmacology, October 1-2, 2010, Novara, Italy
  7. Boldrini M, Burke KM, Leong S, Arango V, Mann JJ, Underwood MD. Neural progenitor cell replication in the hippocampus of alcoholic subjects responds to alcohol levels. 49th ACNP Annual Meeting. Dec 4-9 2010 Miami Beach, FL

2011

  1. Boldrini M, Underwood MD, Burke KM, Dwork AJ, Rosoklija GB, Mann JJ, Arango V. Neuroplasticity in major depression and suicide: regulatory factors. SOBP 66th Annual Meeting, May 12-14, 2011, San Francisco, California, USA
  2. *Burke MK, Simeon LR, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Hen R, Arango V, Boldrini M. Neurogenesis And Angiogenesis Are Correlated In The Adult Human Dentate Gyrus And Both Are Higher With SSRIs In Major Depression. NYSTEM 2011 Meeting May 24-25, 2011 CUNY Graduate center, New York, NY
  3. Boldrini M, Donaldson Z, Bakalian MJ, Kassir SA, Santiago AN, Sullivan B, Underwood MD, Hen R, Mann JJ, Arango V. Anterior-posterior gradient of 5-HT1A receptor expression in the human hippocampus. Society for Neuroscience. November 12-16, 2011. Washington, DC
  4. Boldrini M, Simeon LR, Butt TJ, Bakalian MJ, Burke KM, Underwood MD, Rosoklija GB, Dwork AJ, Hen R, Mann JJ, Arango V. Fewer mature neurons in the anterior dentate gyrus in major depression: Rescue by antidepressants. 50th ACNP Annual Meeting. December 4-8, 2011 Waikaloa Beach, Hawaii

2012

  1. Boldrini M, Butt TH, Simeon LR, Bakalian MJ, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. Benzodiazepines may counteract the trophic effect of antidepressants on granule cells in depressed individuals: a postmortem study. SOBP 67th Annual Meeting, May 3-5, 2012, Philadelphia, PA, USA
  2. *Simeon LR, Musolino G, Butt TH, Bakalian MJ, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Hen R, Arango V, Boldrini M. Immature and mature neuron numbers are higher with antidepressant treatment and lower with major depressive disorder in the human dentate gyrus. Columbia University Stem cell Day, May 7th 2012, New York, NY, USA
  3. *Santiago AN, Kassir SA, Migliarini S, Bakalian MJ, Burke KM, Musolino G, Palavicino-Maggio CB, Rosoklija GB, Dwork AJ, Mann JJ, Pasqualetti M, Hen R, Arango V, Boldrini M. Correlation between 5-HT1A mRNA expression and number of mitotic and progenitor cells in the human hippocampus. Society for Neuroscience. October 13-17, 2012. New Orleans, LA
  4. *Bracci G, Bakalian MJ, Butt TH, Santiago AN, Dwork AJ, Rosoklija GB, Hen R, Tamir H, Arango V, Mann JJ, Boldrini M. Childhood Adversity is Associated with Fewer Immature and Mature Dentate Gyrus Neurons in Treated and Untreated Depressed Subjects But not in Non-Psychiatric Controls. 51st ACNP Annual Meeting. December 2-6, 2012, Hollywood, FL
  5. *Azmitia EC, Kothari PP, Alzoobaee MF, Butt TH, Lyo HK, Jiang G, Whitaker-Azmitia PM, Banerjee P, Boldrini M. Higher Nestin and GFAP Immunoreactivity in Superior Temporal Cortex in Developing Autism Donors 2-21 Yrs of Age Compared To Age-Matched Controls, Evidence for Sustained Cell and Microvessel Proliferation. 51st ACNP Annual Meeting. December 2-6, 2012, Hollywood, FL

2013

  1. *Bracci G, Santiago AN, Butt TH, Bakalian MJ, Laika R. Simeon, Dwork AJ, Rosoklija GB, Hen R, Mann JJ, Boldrini M. Early life adversity impact on hippocampus neuroplasticity in human. SOBP 68th Annual Meeting, May 16-18, 2013, San Francisco, CA, USA
  2. *Maura Boldrini. Adult hippocampal neurogenesis in depression and suicide. IASR 2013 World Congress. June 10-13 Montreal, Canada
  3. *Azmitia EC, Alzoobaee MF, Saini AS, Lyo HK, Butt TH, Wegiel JX, Whitaker-Azmitia PM, Boldrini M. Angiogenesis is increased in autism temporal cortex, study of nestin, vimentin, pericytes and endothelial cells. Society for Neuroscience. November 9-13, 2013. San Diego, CA
  4. *Santiago AN, Liu Y, Bakalian MJ, Dwork AJ, Rosoklija GB, Hen R, Arango V, Mann JJ, Boldrini M. VEGFR2 is increased in antidepressant treated subjects and correlates with neuronal progenitor cells, granule neurons, and vessel measures in the human dentate gyrus. 52nd ACNP Annual Meeting. December 8-12, 2013, Hollywood, FL
  5. *Bracci G, Bakalian MJ, Dwork AJ, Hen R, Rosoklija GB, Arango V, Mann JJ, Boldrini M. Neurotrophins receptor TrkB expression in dentate gyrus and hilus of treated and untreated subjects with major depression correlates with number of neural progenitor cells and neurons. 52nd ACNP Annual Meeting. December 8-12, 2013, Hollywood, FL

Community Service

American Foundation for Suicide Prevention

Children's International Summer Villages

NYC Public Schools

Teaching Responsibilities

Specific Courses

  • 2012 Columbia University, Department of Psychiatry
    New York, NY
    Teaching Assistant, Psychiatric Medicine, PSCYM5101_081_2012_1, first year Medical Students, Columbia University, three hours weekly/bi-weekly
  • 2010 Columbia University, Department of Psychiatry
    New York, NY
    Lecture Teaching, Advanced Psychopharmacology, PGY-4, Psychiatry Residents, Columbia University, two lectures
  • 2002-2003 Univ. of Florence, Dept. of Neurological & Psychiatric Sciences
    Florence, Italy
    Lecture Teaching, Postdoctoral Course: “Psychopathology of Special Populations”, University of Florence, Italy, three lectures

General Teaching Activities (attending, wards service, etc.)

  • 2010 Columbia University, Department of Psychiatry
    New York, NY
    Mentor, 3rd year CU Medical School students
    Rotation in Psychiatry, Eye Institute Outpatient Clinic
  • 2000-2006 Univ. of Florence, Dept. of Neurological & Psychiatric Sciences
    Florence, Italy
    Mentor, Fifth Year Medical School students, rotation in Psychiatry, In-patient Unit
  • 2000-2006 Univ. of Florence, Dept. of Neurological & Psychiatric Sciences
    Florence, Italy
    Mentor, Residents in Psychiatry
  • 2005-2006 Univ. of Florence, Dept. of Neurological & Psychiatric Sciences
    Florence, Italy
    Mentor, Residents in Neurology
  • 2002-2006 Univ. of Florence, Dept. of Neurological & Psychiatric Sciences
    Florence, Italy
    Mentor, Resident in Neuropathology, University of Pisa, Italy

Ph.D./Master’s Theses Trainees

  • 2012-pres. Columbia University
    New York, NY
    Mentor, PhD Students Doctoral Program in Neurobiology & behavior
  • 2000-2006 Univ. of Florence, College of Physicians and Surgeons
    Florence, Italy
    M.D. Thesis Sponsorship, Medical School graduation thesis experimental design, preparation and defense training

Ph.D. Examination-, Advisory -, and Defense Committees

  • 2000-2006 University of Florence, College of Physicians & Surgeons
    Florence, Italy
    Member, Medical School Graduation Thesis Committee

Other Trainee Advisory Roles, e.g. postdoctoral trainees, visiting scientists, student trainees

  • Columbia University, Department of Psychiatry
    New York, NY
    Mentor, Post Doctoral Research Scientist, Dr. Giulia Bracci, M.D., Resident in Psychiatry, Univ. of Pisa, Italy
    2012-pres.
  • Columbia University, Department of Psychiatry
    New York, NY
    Mentor, College student Summer Internships and College Credit Courses
    2008-2010
  • 2010 Oberlin College, Ohio, student Benjamin Sullivan
  • 2008 Columbia University Summer Research Program for Students from Underrepresented Groups
  • 2008 Stony Brook University
  • 2007-2008 Columbia College
  • 2007-2011 Columbia University, Department of Psychiatry New York, NY Mentor, High School student Summer Internships
  • 2011 Fort Lee High School
  • 2011 South High School
  • 2010 Riverdale Country High School
  • 2010 Fort Lee High School
  • 2010 South High School
  • 2007 Syosset High School
  • 2002-2005 Univ. of Florence, Dept. of Neurological & Psychiatric Sciences Florence, Italy
  • Mentor, Post Doctoral Research Scientists

Committees/Societies/Memberships

2007-present             Member: Society for Neuroscience

2008-present             Member: Society of Biological Psychiatry

2010-present             Associate Member: American College of Neuropsychopharmacology

2013-present             Member: International Academy of Suicide Research (IASR)

Global Health Countries

  • Italy
  • United States

Honors & Awards

  • 2015 Invited lecturer, World Congress on Angiogenesis 2015. April 11-12, 2015. Boston, MA
  • 2014  Invited lecturer, Adult Neurogenesis: From Stem Cells to Therapies 1st meeting, February 6-8, 2014, TIFR, Mumbai, India
  • 2013 Invited lecturer, Department of Psychiatry, University of Pittsburgh, April 8,  2013, Pittsburgh, PA,
  • 2013 Grand Round lecturer, Department of Psychiatry, Loyola University, March 13,  2013, Chicago, IL,
  • 2012 Selected presenter, Late-Breaking Session, Society of Biological Psychiatry’s 67th Annual Meeting, May 3-5, 2012, Philadelphia, PA
  • 2011 Grand Round lecturer, Department of Psychiatry, NYU School of Medicine, Woodhull Medical and Mental Health Center, Nov 11, 2011, New York, NY
  • 2011 Invited lecturer, Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies, April 11, 2011, Univ. of Florence, Italy
  • 2010 Kavli Fellow, National Academy of Sciences
  • 2010 Invited lecturer, National Academy of Sciences’ twenty-second annual Kavli Frontiers of Science symposium, Beckmann Center, Nov. 4-6, 2010, Irvine, CA
  • 2010 Invited lecturer, XVII Congress of the Italian Society of Neuropsycho-pharmacology, September 22-25, 2010, Cagliari, CA, Italy
  • 2010 Invited lecturer, Meeting: "Pharmacological Modulation of Adult Neurogenesis", University of Novara, October 1-2, 2010, Novara, Italy
  • 2008  Selected presenter, Hot Topics Basic Session at 47th American College of Neuropsychopharmacology (ACNP) Annual Meeting, December 6-11, 2008,  Scottsdale, AZ
  • 2007   Travel Scholarship, Society of Biological Psychiatry
  • 2006-2008 Janssen Fellow in Translational Neuroscience Research, Columbia University, New York, NY
  • 2000 Invited lecturer, January 11, 2000, Brickell Suicide Research Conference, Columbia University, New York, NY

Research Interests

  • Neuroplasticity in Mood Disorders and Suicide
  • Models of Psychiatric Disorders
  • Neural Degeneration and Repair
  • Stem Cell Biology
  • Psychiatry
  • Neuroplasticity
  • Psychopharmacology

Lab Projects

  • I am currently involved as Principal Investigator or Co-Investigator in research projects studying: 


    1. The relationship between trophic factors expression in the hippocampal dentate gyrus (DG) and its correlation with the amount of neurogenesis and angiogenesis in the human brain.

    2. Human adult neurogenesis in normal subjects and individuals with mood disorders and the effects of antidepressant treatment on human adult neurogenesis. 

    3. Molecules controlling cell proliferation, maturation and survival in depressed suicide compared with non-suicide depressed individuals and controls without psychiatric diagnosis. 

    4. Angiogenesis and cell proliferation in the postmortem temporal cortex of autism donors and matched normal developing individuals. 

Scientific Results

She found that SSRI and in some cases tricyclic and lithium‐treated depressed patients had evidence of more neurogenesis and angiogenesis.

Collaborators

Hen R, Rosoklija GB, Dwork AJ, Arango V, Mann JJ.

Publications

  • 1996 Boldrini M, Placidi GP, Mosca M, Caponi L, Bombardieri S: Psychiatric disorders and immunological parameters in patients with Systemic Lupus Erythematosus. J Neural Transmission 1996; 103:10-18
  • 1997 Toni C, Cappa S, Boldrini M, Frare F, Pedri S, Medda P, Perugi G. Selective neuropsychological dysfunction in patients with panic disorder-agoraphobia. Biological Psychiatry 1997; 42:1s-297s
  • 1997 Toni C, Cappa S, Perugi G, Boldrini M, Frare F, Pedri S, Medda P, Cassano GB: A selective pattern of neuropsychological dysfunction in patients with panic disorder-agoraphobia. CNS Spectrum 1997; 2:64-67
  • 1997 Placidi GP, Boldrini M: Considerations on the role of genetics in psychiatry research. CNS Spectrum 1997; 2:42-44
  • 1997 Placidi GF, Boldrini M, Lenzi A. (1997) Long-term pharmacological treatment of panic disorder. In: Pancheri P, (ed.), Il Punto Su: Terapia Del Disturbo Di Panico, Scientific Press, Florence, Italy
  • 1998 Placidi GPA, Boldrini M, Patronelli A, Fiore E, Chiovato L, Perugi G, Marazziti D: Prevalence of psychiatric disorders in thyroid diseased patients. Neuropsychobiology 1998; 38(4):222-225
  • 1998 Boldrini M, Placidi GPA, Marazziti D (1998). Applications of chaos theories to psychiatry: A review and future perspectives. CNS Spectrum, 3,22-29
  • 1999 Boldrini M, Placidi GP: Neuropsychology of obsessive-compulsive disorder: review and experimental design. Psychiatry Studies 1999; 2:24-29
  • 1999 Toni C, Boldrini M, Frare F, Medda PP. (1999) Neuropsychology of mood disorders. In Cassano GB, Pancheri P, Pavan L, Pazzagli A, Ravizza L, Rossi R, Smeraldi E, Volterra V (ed.), Trattato Italiano di Psichiatria, Second Edition, Masson, Milan, Italy
  • 2001 Arango V, Underwood MD, Boldrini M, Tamir H, Kassir SA, Hsiung SC, Chen JJX, Mann JJ: Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression are reduced in the brainstem of depressed suicide victims. Neuropsychopharmacology 2001; 25(6):892-903
  • 2002 Boldrini M. (2002) New atypical antipsychotics: integration between pharmacotherapy and psychosocial therapy. In: Quetiapine in clinical practice. AstraZeneca (Ed). Il Pensiero Scientifico Editore, Rome, Italy
  • 2002 Placidi G, Boldrini M, Placidi GF. (2002) Olanzapine use in clinical practice. Seven case reports. Il Pensiero Scintifico Editore, Rome, Italy
  • 2003 Mannucci E, Ricca V, Filetti S, Boldrini M, Rotella CM:  Eating behavior and thyroid disease in female obese patients. Eating Behaviors 2003; 4:173-179
  • 2003 Ravaldi C, Vannacci A, Zucchi T, Mannucci E, Cabras PL, Boldrini M, Murciano L, Rotella CM, Ricca V: Eating disorders and body image disturbances among ballet dancers, gymnasium users and body builders. Psychopathology 2003; 36:247-254
  • 2003 Boldrini M, Martini A, Placidi GP, Giromella A, Underwood MD, Kassir SA, Placidi GF, Mann JJ, Arango V: Gender differences in brainstem serotonergic system function in depressed suicides and controls. Journal of Psychopathology 2003; 9:5-7
  • 2003 Boldrini M, Pampaloni I, Placidi GP, Martini A, Underwood MD, Kassir SA, Placidi GF, Mann JJ, Arango V: Rostro-caudal distribution of 5HT1A receptors in the brainstem of suicides and controls. Journal of Psychopathology 2003; 9(Suppl. N. 1):46-49
  • 2003 Placidi GF, Turchi F, Boldrini M, Placidi GP, Murciano L, Arena A: Low cholesterol levels in subjects with mood disorders: association with suicidal behavior. Studies on aggressiveness and suicide 2003; 9:12-19
  • 2003 Boldrini M, Rossi M, Placidi GF. Paroxetine efficacy in stuttering treatment. Int J Neuropsychopharmacol. 2003; Sep;6(3):311-2
  • 2004 Del Rosso A, Boldrini M, D'Agostino D, Placidi GP, Scarpato A, Pignone A, Generini S, Konntinen Y, Zoppi M, Vlak T, Placidi GF, Matucci-Cerinic M: Health related quality of life in systemic sclerosis as measured by SF 36: relationship with clinical and biological markers. Arthritis & Rheumatism (Arthritis Care & Research) 2004; 51(3):475-481
  • 2004 Ricca V, Nacmias B, Boldrini M, Cellini E, Di Bernardo M, Ravaldi C, Rotella CM, Sorbi S: Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from anorexia nervosa and bulimia nervosa. Neurosci Letters 2004; 365(2):92-96
  • 2005 Boldrini M, Del Pace L, Placidi GP, Keilp J, Ellis SP, Signori S, Placidi GF, Cappa SF: Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. Acta Psychiatr Scand 2005; Feb;111(2):150-158
  • 2005 Boldrini M, Underwood MD, Mann JJ, Arango V: More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. Brain Res 2005; Apr 11;1041(1):19-28
  • 2005 Boldrini M, Giromella A, Martini A, Rossi M, Becherini F, Castagna M, Sorbi S, Placidi GF: Serotonin transporter density in cortical areas of subjects with Alzheimer Disease and controls. Journal of Psychopathology 2005; 9(Suppl. N. 1):13-20
  • 2008 Boldrini M, Underwood MD, Mann JJ, Arango V. Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. J Psychiatr Res 2008; May;42(6):433-442
  • 2009 Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 2009; 34(11):2376-2389 e-Pub ahead of print. PM:19606083
  • 2010 Boldrini M, Arango V. Antidepressants, age and neuroprogenitors. Neuropsychopharmacology. 2010 Jan;35(1):351-352. doi: 10.1038/npp.2009.130
  • 2010 Boldrini M, Underwood MD, Mann JJ, Arango V. Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. [Unión al autorreceptor 5-HT1A de la serotonina en el núcleo dorsal del rafe en muestras de tejido de víctimas de suicidio deprimidas]. Psiquiatria Biologica. Volume 17, Issue 1, January 2010, Pages 12-21
  • 2010 Boldrini M, Arango V. Consequences of the Stress Response: Stress and suicide. In: L.R. Squire (Ed.) New Encyclopedia of Neuroscience, Elsevier, Oxford, UK. 2010, Pages 471-479
  • 2012 Boldrini M, Hen R, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V. Hippocampal Angiogenesis and Progenitor Cell Proliferation are Increased with Antidepressant Use in Major Depression. Biol Psychiatry. 2012 Oct 1;72(7):562-571.
  • 2013 Boldrini M, Santiago AN, Hen R, Dwork AJ, Rosoklija GB, Tamir H, Arango V Mann JJ. Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology. 2013 Jan 7. doi: 10.1038/npp.2013.
  • 2014 Wu MV, Shamy JL, Bedi G, Choi CW, Wall MM, Arango V, Boldrini M, Foltin RW, Hen R. Impact of Social Status and Antidepressant Treatment on Neurogenesis in the Baboon Hippocampus. Neuropsychopharmacology. 2014 Feb 12. doi: 10.1038/npp.2014.33. PMID: 24518288
  • 2014 Mann JJ, Oquendo MA, Watson KT, Boldrini M, Malone KM, Ellis SP, Sullivan G, Cooper TB, Xie S, Currier D. Anxiety in Major Depression and Cerebrospinal Fluid Free Gamma-Aminobutyric Acid. Depression and Anxiety. Depress Anxiety. 2014 May 27. doi: 10.1002/da.22278. PMID: 24865448
  • 2014 Boldrini M, Butt TH, Dwork AJ, Bakalian MJ, Tamir H, Rosoklija GB, Hen R, Arango V Mann JJ. Benzodiazepines And The Potential Trophic Effect Of Antidepressants On Dentate Gyrus Cells In Mood Disorders. Int J Neuropsychopharmacol 2014 Jun 27:1-11. PMID: 24969726
  • 2014 Boldrini M, Mann JJ. (2014) Depression and Suicide. In: Neurobiology of Brain Disorders. Biological Basis of Neurological and Psychiatric Disorders. Edited by Michael J. Zigmond, Joseph T. Coyle and Lewis P. Rowland. Elsevier, San Diego, CA, USA, 2014. Pages 709-729
  • 2015  Azmitia EC, Saccomano ZT, Alzoobaee ZF, Boldrini M, Whitaker-Azmitia PM. Persistent Angiogenesis in the Autism Brain: an immunocytochemical study of postmortem cortex, brainstem and cerebellum. Journal of Autism and Developmental Disorders (JADD). 2015 Dec 14. [Epub ahead of print] PMID: 26667147
  • 2016 Donaldson ZR, Le Francois B, Santos TL, Almli LM, Boldrini M, Champagne F, Arango V, Stockmeier CA, Galfalvy H, Albert PR, Ressler KJ, Hen R. The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription. Translational Psychiatry. 2016 Mar 1;6:e746. doi: 10.1038/tp.2015.226. PMID: 26926882 
  • 2016 Aizenstein HJ, BaskysA, Boldrini M, Butters MA, Diniz B, Jaiswal MJ, Jellinger KA, Kruglov LS, Meshandin IA, Mijajlovic MD, Niklewski G, Pospos S, Raju K, Richter K, Steffens DC, Taylor W, Tene O. Vascular Depression Consensus Report – UPDATED. BMC Medicine, In press

For a complete list of publications, please visit PubMed.gov