Holly Moore, PhD

Departments And Divisions

  • Department of Psychiatry
    Division of Integrative Neuroscience
  • Associate Professor of Clinical Neurobiology (in Psychiatry)
Holly Moore, <span>PhD</span>

Limbic-related cortical regions, including hippocampus, parahippocampal, medial prefrontal and cingulate cortices, and the nuclei in the basal forebrain, midbrain and hindbrain that are innervated by these regions, regulate cognitive and behavioral processes that provide the animal what it needs (e.g. food, water, sex, avoidance or escape from threatening situations). One of the goals of our research is to study how interactions between environmental factors and limbic-related circuits can lead to the pathophysiology and behavioral symptoms of schizophrenia and depression.

Our general approach is to expose the animal to a physiological or psychological stressor, then study the behavioral, neurochemical and neurophysiological effects that persist after the stressor is removed. As part of the Lieber Center for Schizophrenia Research, we study the impact of altered DNA methylation on the development of the cerebral cortex and cortical-to-subcortical circuits that mediate cognition and motivation. We have found that a disruption of DNA methylation, occurring early in development, leads to abnormal physiology of limbic cortical and related subcortical neurons in the mature animal.

Moreover, animals with early disruption of limbic cortical development show cognitive and motivational behavioral abnormalities that correlate with the neurophysiological abnormalities. We also study the effects of stress on the physiology of limbic cortical-subcortical circuits and the behaviors mediated by these circuits. Our collaboration with other laboratories in the training program provides us with opportunities to study the impact of specific genes on limbic brain circuits.

Lab Locations

  • Herbert Pardes Building of the New York State Psychiatric Institute

    1051 Riverside Drive
    Room 5911C, Unit/Box 14
    New York, NY 10032
    Phone:
    (646) 774-5246
    Email:
    hm2035@cumc.columbia.edu

Research Interests

  • Models of Psychiatric Disorders
  • Neurobiology of Disease
  • Preclinical Models of Psychotic and Mood Disorders
  • Rodent Behavioral Assessment and Psychopharmacology
  • Neurophysiology and Neurochemistry of Cortico-Basal Ganglia and Dopamine Circuits

Publications

  • Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA (2006) A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol cetate on E17: Implications for the Neuropathology of Schizophrenia. Biological Psychiatry, 60, 253-264.
  • Schobel SA, Lewandowski NM, Corcoran C, Moore H, Brown T, Malaspina D & Small SA (2009) The CA1 subfield of the hippocampal formation is differentially targeted by schizophrenia and related psychotic disorders. Archives of General Psychiatry, 66, 938 - 946.
  • Moore H (2010) The role of rodent models in the discovery of new treatments for schizophrenia: Updating our strategy, Schizophrenia Bulletin, 36, 1066-1072.
  • Cressman VL, Balaban J, Steinfeld S, Shemyakin A, Graham P, Parisot N & Moore H. (2010) Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat, Journal of Comparative Neurology, 518, 2693-2709.
  • Moore, H., et al. (2013). "Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models." Neurosci Biobehav Rev 37: 2087-2091.
  • Schobel, S. A., et al. (2013). "Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver." Neuron 78: 81-93.
  • Gilani, A. I., et al. (2014). "Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition." Proc Natl Acad Sci USA 111: 7450-7455.
  • Cazorla, M., et al. (2014). "Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry." Neuron 81: 153-164.