Departments And Divisions
- Department of Genetics & Development
- Professor of Genetics & Development
During development, cells are programmed to generate and interpret spatial information so that every cell within a population knows where it is and what to do as a consequence. Dr. Struhl's work uses genetical and molecular approaches in Drosophila to address the fundamental questions (i) what is spatial information?, (ii) how is it generated?, and (iii) how is it interpreted? His work has led to discoveries about the nature and mode action of spatial determinants controlling cell and body patterns, tissue growth and planar cell polarity. These include (i) the Polycomb and HOX “selectors” in specifying body segments; (ii) the transcription and translation factors Bicoid, Caudal, Hunchback and Nanos in organizing global body pattern, (iii) secreted factors of the Hedgehog, Wnt, and BMP/TGFb superfamilies as the first, intercellular gradient morphogens, (iv) Delta/Notch signaling in cell-fate specification, and (v) the serpentine receptors Frizzled and Starry night, and the atypical cadherins Dachsous and Fat, in planar cell polarity.
Jerome L. Greene Science Center3227 Broadway
New York, NY 10027
- (212) 853-3575
- Cell Specification and Differentiation
- Cellular/molecular/Developmental Neuroscience
Chen, C.-M., Strapps, W., Tomlinson, A. and Struhl, G (2004). Evidencethat the cysteine -rich domain of Drosophila Frizzled family receptorsis dispensible for transducing Wingless. Proc. Nat. Acad. Sci. U.S.A.,101: 15961-15966.
Wang, W. and Struhl, G. (2004). DSL ligands must undergo Epsin-mediatedendocytosis to activate Notch in Drosophila. Development 131: 5367-80.
Lawrence, P.A., Casal, J. and Struhl, G. (2004). Cell interactions andplanar polarity in the abdominal epidermis of Drosophila. Development131: 4651-4664.
Casali, A. and Struhl, G. (2004). Measuring morphogen concentration asa function of the ratio of bound to unbound receptor. Nature 431: 76-80.
Struhl, G. and Adachi, A. (2000). Requirements for Presenilin-dependentcleavage of Notch and other transmembrane proteins. Molecular Cell 6:625-636.
Lawrence, P.A., and Struhl, G. (1996). Morphogens, Compartments and Pattern: Lessons from Drosophila? Cell 85: 951-961.