Eric Kandel, MD

Departments And Divisions

  • Department of Biochemistry and Molecular Biophysics
  • Department of Neuroscience
  • Department of Physiology & Cellular Biophysics
  • Department of Psychiatry
    Division of Neurobiology and Behavior
  • University Professor
  • Kavli Professor of Brain Science
  • Director, Kavli Institute for Brain Science
  • Co-Director, Mortimer B. Zuckerman Mind Brain Behavior Institute
Eric Kandel, <span>MD</span>

We combine behavioral, cellular, and molecular biological approaches to delineate the changes that underlie simple forms of learning and memory in invertebrates and vertebrates. In invertebrates the focus of our research is on the gill-withdrawal reflex of Aplysia. We study three elementary forms of learning: habituation, sensitization, and classical conditioning. Recently we have reconstituted critical components of this learning in dissociated cell culture, and we now use the reconstituted system to examine the molecular mechanisms which contribute to short- and long-term memory.

In vertebrates we use genetically modified mice to examine the mechanisms of long-term potentiation in the mammalian hippocampus and its relation to spacial memory and maintenance. 

Lab Locations

  • NYSPI-Kolb Research Building

    40 Haven Avenue
    Box 87
    New York, NY 10032
    Phone:
    (646) 774-6825
    Email:
    erk5@cumc.columbia.edu

Honors & Awards

  • 2000, Nobel Prize in Physiology or Medicine
  • Senior Investigator, Howard Hughes Medical Institute

Research Interests

  • Neurogenetics
  • Models of Psychiatric Disorders
  • Neurobiology of Learning and Memory
  • Biophysics/Ion Channels
  • Synapses and Circuits
  • Systems and Circuits

Publications

  • Kandel, ER. The New Science of Mind and the Future of Knowledge. (2013) Neuron 80:546-560.
  • Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, Small SA, Kandel ER. Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48. (2013) Sci Transl Med 5:200ra115.
  • Rajasethupathy P, Antonov I, Sheridan R, Frey S, Sander C, Tuschl T, Kandel ER. (2012). A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity. Cell 149: 693-707.
  • Levine A, Huang Y, Drisaldi B, Griffin EA Jr, Pollak DD, Xu S, Yin D, Schaffran C, Kandel DB, Kandel ER. (2011) Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine. Sci Transl Med 3: 107ra109.
  • Choi YB, Li HL, Kassabov SR, Jin I, Puthanveettil SV, Karl KA, Bailey CH, Kandel ER. (2011) Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in Aplysia. Neuron 70: 468-481.
  • Fiumara F, Fioriti L, Kandel ER, Hendrickson WA. (2010) Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins. Cell 143: 1121-1135.
  • Akil, H., Brenner, S., Kandel, E.R., Kendler, K.S., King, M-C., Scolnick, E., Watson, J.D., and Zoghbi, H.Y. (2010) The future of psychiatric research: Genomes and neural circuits. Science 327:1580-1581.
  • Simpson, E.H., Kellendonk, C., and Kandel, E.R. (2010) A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia. Neuron 65:585-596.
  • Si, K., Choi, Y., White-Grindley, E., Majumbar, A., and Kandel, E.R. (2010) Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation. Cell 140:421-435.

For a complete list of publications, please visit PubMed.gov