Edmund Au, PhD

Departments And Divisions

  • Department of Pathology & Cell Biology
  • Assistant Professor of Pathology & Cell Biology
Edmund Au, <span>PhD</span>

The Au lab studies cortical interneurons, a diverse population of locally-projecting GABAergic cells. They are involved in regulating spike timing, signal refinement and cortical oscillations, all of which are critical to normal brain function. We are primarily focused on how cortical interneurons wire into cortical circuitry developmentally, as well as their role in mental illness.

Our general approach is to apply developmental genetics to the differentiation of stem cells into specific interneuron subtypes. In order to study these cells in their native environment, they are transplanted in utero and we study their integration into host cortex. Since stem cells start off as a blank slate, we have the opportunity to manipulate various stages of interneuron differentiation and maturation by manipulating the cells in vitro. In this manner, we can therefore delve into molecular mechanisms that govern the process of microcircuit assembly.

Dysfunction in cortical interneurons has been linked to a number of diseases including autism spectrum disorder, schizophrenia, epilepsy and attention deficit and hyperactivity disorder. We are interested in employing stem cell-based approaches to model neuropsychiatric disorders in order to study underlying disease mechanisms. From these studies we hope to pave the way towards more directed, specific and effective treatments for psychiatric ailments.

Lab Locations

  • Presbyterian Hospital Building (PH)

    622 West 168th Street
    PH1564
    New York, NY 10032
    Email:
    ea2515@columbia.edu

Research Interests

  • Cell Lineage Specification
  • Neuronal Migration
  • Synaptic Specificity
  • Models of Psychiatric Illness

Publications

Karayannis* T, Au E*, Patel J., Kruglikov I., Markx S., Delorme R., Heron D, Glessner J., Restituito S., Gordon A., Roy N.C., Gogos J., Rudy B., Rice M.E., Karyiorgou M., Hakonarson H., Bourgeron T., Hoeffer C., Tsien R.W., Peles E., Fishell G. (2014) Cntnap4 differentially contributes to GABAergic and Dopaminergic Synaptic Transmission. Nature. 511(7508): 236-40.

Au E., Ahmed T, Karayannis T., Biswas S., Gan L., Fishell G. (2013) A modular gain-offunction approach to generate cortical interneuron subtypes from ES cells. Neuron. 80(5): 1145-58.

Au E., Fishell G. (2008) Cortex shatters glass ceiling. Cell Stem Cell 3(5): 472-4.

Au E., Richter M.W., Vincent A.J., Tetzlaff W., Aebersold R., Sage E.H., Roskams A.J. (2007) SPARC from olfactory ensheathing cells stimulates Schwann cells to promote neurite outgrowth and enhances spinal cord repair. The Journal of Neuroscience. 27(27): 7208-21.

Au E, Fishell, G. (2006) Adult cortical neurogenesis: nuanced, negligible or nonexistent? Nature Neuroscience. 9: 1086-1088.