E. David Leonardo, MD, PhD

Departments And Divisions

  • Department of Psychiatry
    Division of Integrative Neuroscience
  • Assistant Professor of Psychiatry at CUMC
E. David Leonardo, <span>MD, PhD</span>

Our primary interest is in understanding how temporal factors, genetic risk, and environmental milieu interact to impact on the expression of mental illness.  As the brain develops, distinct neural circuits develop within narrowly defined time periods. These precisely defined time windows provide the opportunity for short-lived gene X environment interactions that ultimately determine the functioning of mature circuitry and the behaviors that they mediate. In a longstanding collaboration with Alex Dranovsky, we are examining the effects of stressful and enriching experiences on mature and immature brain circuitry in the mouse, with the aim of understanding how such effects produce alterations in behavior.

In another area of investigation, we use novel, regulatable, serotonin-1A receptor mutant mice to disrupt normal serotonergic signaling in early development.  Using this system, we can independently manipulate either specific cortical 5-HT1A medicated signaling by selectively removing cortical receptors, or globally disrupt serotonergic signaling by removing 5-HT1A receptors in the raphe, which provide negative feedback for serotonergic neurons.  Using this model system, we have already identified distinct effects of cortical receptors on depression related behavior and raphe receptors on anxiety related behavior.  We are currently investigating the time course during which the distinct circuits mediating these behaviors are vulnerable to disruption.

Board Certifications

  • Psychiatry

Areas of Expertise

  • General Psychiatry / Psychology
  • Depression
  • Anxiety Disorders
  • Adult Psychiatry
  • Anxiety and Depression

    Education & Training

  • 1999 University of California San Francisco School of Medicine
  • Internship: 2001 New York State Psychiatric Institute
  • Residency: 2003 NewYork-Presbyterian Hospital/Columbia University Medical Center

Locations

  • 119 West 57th Street Office

    119 West 57th Street
    Suite: 620
    New York, NY 10019
    Phone:
    (917) 751-5542
    For new and current patient appointments, call:
    (646) 774-7105
    Fax:
    (866) 284-5724
  • Herbert Pardes Building of the New York State Psychiatric Institute

    1051 Riverside Drive
    New York, NY 10032
    Phone:
    (646) 774-7105
    Fax:
    (646) 774-7117

Provider Affiliations

  • NewYork-Presbyterian/Columbia

Lab Locations

  • Kolb Research Annex

    40 Haven Avenue
    Unit 87, Room 157A
    New York, NY 10032
    Phone:
    (646) 774-7105
    Email:
    el367@cumc.columbia.edu

Contact Info

  • 646-774-7105
  • 866-284-5724

Research Interests

  • Neurogenetics
  • Synapses and Circuits
  • Models of Psychiatric Disorders
  • Neurobiology of Disease
  • Mood Disorder

Publications

  • Garcia-Garcia, A.L., Meng, Q., Richardson-Jones, J., Dranovsky, A., Leonardo, E.D. (2015) Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. doi:10.1016/j.neuroscience.2015.05.076.
  • Kirshenbaum GS, Lieberman SR, Briner TJ, Leonardo ED, Dranovsky A. (2014) Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat. Front Behav Neurosci. 8:289.
  • Richardson-Jones JW1, Craige CP, Guiard BP, Stephen A, Metzger KL, Kung HF, Gardier AM, Dranovsky A, David DJ, Beck SG, Hen R, Leonardo ED. (2010) 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron. 65:40-52. doi: 10.1016/j.neuron.2009.12.003.
  • Leonardo, E.D. (2010). 5-HT1A autoreceptors determine vulnerability to stress and response to antidepressants. Neuron 65: 40-52.
  • Leonardo, E. D., and Hen, R.¬† (2007) Anxiety as a Developmental Disorder. Neuropsychopharmacology reviews¬† 2007: 1: 1-7.