Claudia Schmauss, MD

Departments And Divisions

  • Department of Psychiatry
    Division of Molecular Therapeutics
  • Associate Professor of Psychiatry
  • Vice Chair, Institutional Animal Care and Use Committee at Columbia University
Claudia Schmauss, <span>MD</span>

We are interested in unraveling molecular mechanisms underlying gene expression changes in psychopathological states.

The main focus of our research is on the role of gene x environment interaction in modulating adult behavioral phenotypes. We are conducting molecular, anatomic, and behavioral studies on animal models of depression-like behaviors and animal models of cognitive dysfunctions to study the role of epigenetic changes in gene expression in psychopathological states.

Lab Locations

  • Herbert Pardes Building of the New York State Psychiatric Institute

    1051 Riverside Drive
    Unit 62
    New York, NY 10032
    Phone:
    (646) 774-8710
    Email:
    cs581@cumc.columbia.edu

Past Positions

1991-1996 - Assistant Professor, Department of Psychiatry and Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY

1997-1998 - Associate Professor, Department of Psychiatry and Brookdale Center for Molecular and Developmental Biology, Mount Sinai School of Medicine, New York, NY

1998-2005 - Associate Professor of Psychiatry, Department of Psychiatry, Columbia University, New York NY

1998-present - Research Scientist V, New York State Psychiatric Institute, New York, NY

2005-present - Associate Professor of Psychiatry (tenured), Department of Psychiatry, Columbia University, New York, NY

Committees/Societies/Memberships

Society for Neuroscience, member

American Association for the Advancement of Science, member

Honors & Awards

HONORS:                

1987                Otto Hahn Research Award sponsored by the Max Planck Society, Germany 

1996                Irma T. Hirschl Career Scientist Award

2001                Essel Investigator (NARSAD)

2004                Lieber Investigator (NARSAD)

Research Interests

  • Models of Psychiatric Disorders
  • Cognitive/Systems Neuroscience

Lab Projects

  • Projects on various mouse models aim at addressing: 

    1. Epigenetic modulation of antidepressant efficacy

    2. Transgenerational effects of early life stress

    3. Epigenetic regulation of RNA processing in brain

Publications

  • Schmauss, C. (2015). An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine. Sci. Rep. 5, 8171; DPI:10.1038/srep08171.
  • Schmauss, C., Lee-McDermott, Z., and Ramos Medina, L. (2014). Trans-generational effects of early life stress: The role of maternal behavior. Sci. Rep. 4, 4873; DOI:10.1038/srep04873.
  • Zimnisky, R., Chang, G., Gyertyán, I., Kiss, B., Adham, N., and Schmauss, C. (2013). Carprazine, a dopamine D3-receptor-preferring partial agonist, blocks PCP-induced impairment of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacol. 226: 91-100.
  • Levine, A., Worrell, T.R., Zimnisky, R., and Schmauss, C. (2012). Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment. Neurobiol. Dis. 45: 488-498.
  • Mehta, M. and Schmauss, C. (2011). Strain-specific cognitive deficits in adult mice exposed to early life stress. Behav. Neurosci. 125: 29-36.
  • Navailles, S., Zimnisky, R., and Schmauss, C. (2010). Expression of glucocorticoid receptor and early growth response gene 1 during postnatal development of two inbred strains of mice exposed to early life stress. Dev. Neurosci. 32: 139-148.
  • Schmauss, C., Zimnisky, R., Mehta, M, and Shapiro L.P. (2010). The roles of phospholipase C activation and alternative ADAR1 and ADAR2 pre-mRNA splicing in modulating serotonin 2C-receptor editing in vivo. RNA 16: 1779-1785.

For a complete list of publications, please visit PubMed.gov