Past Events

Dr. Steve Ramirez

Artificially modulating positive and negative memories in healthy and maladaptive states

January 11, 2018 12:00 pm - 1:00 pm

Hellman Auditorium, NY State Psychiatric Institute, Pardes Building, 1051 Riverside Drive, New York NY

With the accumulation of our knowledge about how memories are formed, retrieved, and updated, neuroscience is now reaching a point where discrete memories can be identified and manipulated at rapid timescales. Here, I will review recent advances in memory research that combine transgenic, optogenetic, in vivo imaging, and viral-tracing strategies to visualize and manipulate discrete sets of cells sufficient to modulate mnemonic processes. I will focus on three lines of research: acutely activating and visualizing hippocampus cells to drive the behavioral expression of positive and negative memories; acutely activating cells processing positive memories to suppress the return of fear; and, chronically activating cells processing positive and negative memories to enduringly modulate social and hedonic-like states. Together, I propose that defined sets of hippocampus cells provide a neuronal node sufficient to permanently alter healthy and maladaptive states

Samuel Clark

Characterization striatal direct and indirect path neurons during motor learning and anxiety

December 15, 2017 12:00 pm - 1:00 pm

Hellman Auditorium, Pardes Building, NYSPI, 1051 Riverside Drive

Thesis Defense Seminar

Mary Youssef

Developmental manipulation of the hippocampal dentate gyrus to investigate effects of early life stress on adult dentate function

December 15, 2017 10:00 am - 11:00 am

Hellman Auditorium, Pardes building, NYSPI, 1051 Riverside Drive

Thesis Defense Seminar

Dr. Kwanghun Chung

Towards holistic imaging and phenotyping of intact biological systems

December 14, 2017 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

Holistic measurement of diverse functional, anatomical, and molecular traits that span multiple levels, from molecules to cells to an entire system, remains a major challenge in biology. In this talk, I will introduce a series of technologies including CLARITY, SWITCH, MAP (Magnified Analysis of Proteome), and stochastic electrotransport that enable proteomic and structural imaging for scalable, integrated, high-dimensional phenotyping of both animal tissues and human clinical samples. SWITCH enables over twenty rounds of relabeling of a single tissue with precise co-registration of multiple datasets by synchronizing key chemical reactions in tissue processing. With SWITCH, we demonstrated combinatorial protein expression profiling and high-dimensional quantitative analysis of the human cortex. MAP enables scalable superresolution proteomic imaging of large scale tissues by expanding intact organs four fold linearly while preserving their 3D proteome, nanoscopic architecture, and intercellular connectivity. Using MAP, we demonstrated molecular imaging of subcellular architectures and accurate tracing of densely packed neural projections. To speed up the labeling process in CLARITY, SWITCH, and MAP, we developed a novel electrokinetic method termed stochastic electrotransport, which enables immunolabeling of whole mouse brains within 1-3 days. We hope these new technologies to accelerate the phase of discovery in a broad range of biomedical research.

Graduate Student Research in Progress Talks

Presenters: Neeli Mishra and Sebi Rolotti

December 11, 2017 5:00 pm - 6:00 pm

HHSC 5th floor Conference Room

Dr. Greg DeAngelis

Neural Mechanisms for Perceiving Object Motion During Self-Motion

December 7, 2017 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

Andrew Fielding Huxley: Channels, Effectors and Imaging

A Symposium in Honor of the Centenary of Andrew Fielding Huxley

December 5, 2017 9:00 am - 6:00 pm

Caspary Audiorium, The Rockefeller University, 1230 York Ave., New York NY 10065

Sponsored by: The Shelby White and Leon Levy Center for Mind, Brain and Behavior; The Center for Neural Science and the Neuroscience Institute at New York University; The Mortimer B. Zuckerman Mind Brain Behavior Institute at Columbia University.

Dr. Guoping Feng

Thalamic Reticular Nucleus Dysfunction in Neurodevelopmental Disorders

November 30, 2017 12:00 pm - 1:00 pm

Neurological Institute Alumni Auditorium

The Thirty-Ninth Annual W. Alden Spencer Award and Lecture

Dr. Ardem Patapoutian, The Scripps Research Institute and Dr. David Ginty, Harvard Medical School and HHMI Investigator

November 28, 2017 5:00 pm - 6:30 pm

Vagelos Educational Center, Room 201, 104 Haven Avenue

Graduate Student Research in Progress Talks

Presenters: Melissa Lee and Rebecca Rabinovich

November 20, 2017 5:00 pm - 6:00 pm

HHSC 5th Floor Conference Room